Norepinephrine and dobutamine improve cardiac index equally by supporting opposite sides of the heart in an experimental model of chronic pulmonary hypertension

Abstract Background Pulmonary hypertension is a significant risk factor in patients undergoing surgery. The combined effects of general anaesthesia and positive pressure ventilation can aggravate this condition cause increased pulmonary blood pressures, reduced systemic pressures ventricular contractility. Although perioperative use inotropic support or vasopressors almost mandatory for these patients, preference disputed. In study, we investigated the norepinephrine dobutamine their ability to improve arterio-ventricular relationship haemodynamics pigs suffering from chronic hypertension. Method was induced five by banding artery at 2–3 weeks age. Six served as controls. After 16 banding, animals were re-examined under using biventricular conductance catheters catheter. baseline measurements, exposed both infusions incremental doses, with stabilising period between infusions. hypothesis differences doses tested repeated two-way ANOVA Bonferroni multiple comparisons post-test. Results At baseline, artery-banded had right (+ 39%, p = 0.04), lower cardiac index (? 23% systolic 13%, 0.02) left end-diastolic volume 33%, 0.02). When administered, coupling improved only ( < 0.05). Norepinephrine contractility greater extent 0.05) animals. While equally treatments animals, significantly effect on mean arterial diastolic Conclusion equally, it obtained different manners. Dobutamine function coupling. resistance, thereby improving maintaining volume.